Pharmacokinetics of Dibutylphthalate in Pregnant Rats
نویسندگان
چکیده
منابع مشابه
Pharmacokinetics of dibutylphthalate in pregnant rats.
Dibutylphthalate (DBP) can cause adverse effects on the developing male reproductive tract when administered late in gestation to pregnant rats. The objectives of this study were to evaluate the metabolism of DBP in female rats, and the pharmacokinetics of DBP in pregnant rats on gestational day (g.d.) 20. The identities of DBP metabolites in urine and in maternal and fetal plasma were confirme...
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متن کاملPopulation pharmacokinetics of abacavir in pregnant women.
For the first time, a population approach was used to describe abacavir (ABC) pharmacokinetics in HIV-infected pregnant and nonpregnant women. A total of 266 samples from 150 women were obtained. No covariate effect (from age, body weight, pregnancy, or gestational age) on ABC pharmacokinetics was found. Thus, it seems unnecessary to adapt the ABC dosing regimen during pregnancy.
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2004
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfh294